Chemistry 202 is [Mostly] Painless

Parody of “Suicide is Painless” by Johnny Mandel.

Lyrics:
A stronger acid has a higher ka and a lower PKa
A stronger acid has a weaker conjugate base which is more stable
A stronger base will dissociate and react with a substrate
But a weaker is less likely as its stability keeps it less reactive
And too find a more stable conjugate base please remember SERHI:
Size, electronegativity, resonance, hybridization, induction all create a more stable molecule
A larger anion has much more room over which to spread out negative charge.
But please remember that the size effect only works going down a group on the periodic table.
A more electronegative atom will have greater attraction for an electron pair stabilizing the negative charge
Resonance allows negative charge to be delocalized over more atoms. In the real-world molecules are in a mixture of structures.
Those with more S character hybridization have electron density closer to the nucleus, increasing energy.
The Inductive effect relies on electronegative atoms. Withdrawing electron density and delocalizing negative charge.
But the inductive effect can decrease. As the distance between an electronegative atom and that with the negative charge increases.
And too find a more stable conjugate base please remember SERHI:
Size, electronegativity, resonance, hybridization, induction all create a more stable molecule

Painless